tert-Butyl (1-hydroxy-2-methylpropan-2-yl)

tert-Butyl (1-hydroxy-2-methylpropan-2-yl) - Names and Identifiers

Name	N-Boc-2-Amino-2-Methyl-1-Propanol
Synonyms	N-Boc-2-aMino-2-Methylpropan-1-ol N-Boc-2-Amino-2-Methyl-1-Propanol N-Boc-2-Amino-2-Methyl-1-Propanol 97 N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 tert-Butyl (1-hydroxy-2-methylpropan-2-yl) tert-butyl (1-hydroxy-2-methylpropan-2-yl)carbamate tert-Butyl N-(2-hydroxy-1,1-dimethylethyl)carbamate tert-Butyl (1-hydroxy-2-Methylpropan-2-yl)carbaMate Carbamic acid,N-(2-hydroxy-1,1-dimethylethyl)-, 1,1-dimethylethyl ester 1,1-Dimethylethyl (2-hydroxy-1,1-dimethylethyl)carbamate, 2-Hydroxy-1,1-dimethylethyl)carbamic acid 1,1-dimethylethyl ester, (2-Hydroxy-1,1-dimethylethyl)carbamic acid tert-butyl ester 1,1-Dimethylethyl (2-hydroxy-1,1-dimethylethyl)carbamate, 2-Hydroxy-1,1-dimethylethyl)carbamic acid 1,1-dimethylethyl ester, (2-Hydroxy-1,1-dimethylethyl)carbamic acid tert-butyl ester
CAS	102520-97-8
InChI	InChI=1/C9H19NO3/c1-8(2,3)13-7(12)10-9(4,5)6-11/h11H,6H2,1-5H3,(H,10,12)

tert-Butyl (1-hydroxy-2-methylpropan-2-yl) - Physico-chemical Properties

Molecular Formula	C9H19NO3
Molar Mass	189.25
Density	1.012±0.06 g/cm3(Predicted)
Melting Point	57-62 °C
Boling Point	286.5±23.0 °C(Predicted)
Flash Point	127.097°C
Vapor Presure	0mmHg at 25°C
pKa	12.24±0.46(Predicted)
Storage Condition	2-8°C
Refractive Index	1.453
Physical and Chemical Properties	WGK Germany:2

tert-Butyl (1-hydroxy-2-methylpropan-2-yl) - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	2

tert-Butyl (1-hydroxy-2-methylpropan-2-yl) - Introduction

N-Boc-2-Amino -2-methyl -1-propanol is an organic compound, often abbreviated as Boc-APC. The following is a description of its nature, use, preparation and safety information:

Nature:
N-Boc-2-Amino -2-methyl -1-propanol is a solid compound with the chemical formula C9H19NO3. It has a colorless or white crystalline form and is deliquescent. The compound has a density of about 1.08g/cm³ and a melting point of about 75-78 degrees Celsius.

Use:
N-Boc-2-Amino -2-methyl -1-propanol is widely used in organic synthesis to prepare a variety of compounds. It is often used as a protecting group capable of protecting the amine function to which it is attached. It can be removed from the target compound by a deprotection reaction. In addition, it can also be used as an intermediate in the synthesis of drugs, natural products and other organic synthesis reactions.

Preparation Method:
The preparation method of N-Boc-2-amino -2-methyl -1-propanol is mainly carried out through the following steps: first, 2-amino -2-methyl -1-propanol and dimethylaminopropanol (DMAP) are reacted under alkaline conditions to obtain an intermediate; then, phthalic anhydride (N-Boc-OSu) is used to react with the intermediate to form N-Boc-2-amino -2-methyl -1-propanol; finally, the pure product was obtained by purification methods such as crystallization or column chromatography.

Safety Information:
N-Boc-2-amino -2-methyl -1-propanol is an organic compound, which is relatively stable under general conditions. However, it is a deliquescent compound and should be kept away from humid air and moisture. In addition, it has an irritating effect on the eyes, skin and the respiratory tract of the human body. Appropriate laboratory safety measures should be taken when handling and using the compound, such as wearing protective glasses, laboratory clothing and gloves, and ensuring good ventilation.

Last Update：2024-04-09 21:01:54